Solid phase synthesis of pyridine-based derivatives from a 2-chloro-5-bromopyridine scaffold.
作者信息
Pierrat Philippe, Gros Philippe C, Fort Yves
机构信息
Synthèse Organométallique et Réactivité, UMR 7565, Faculté des Sciences, Université Henri Poincaré, Boulevard des Aiguillettes, BP 239, 54506 Vandoeuvre-lès-Nancy, France.
出版信息
J Comb Chem. 2005 Nov-Dec;7(6):879-86. doi: 10.1021/cc050054a.
PMID:16283796
Abstract
2-Chloro-5-bromopyridine was immobilized on polystyrene via selective introduction of a traceless silicon linker at the C-4 position. A useful scaffold was thus obtained, as demonstrated by efficient and selective reactions with polar and transition organometallic reagents, opening a new access to pyridine-based libraries of synthons and chromophores.
摘要
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