RNA干扰：RNA诱导沉默复合体被加载。
RNAi: RISC gets loaded.
作者信息
Preall Jonathan B, Sontheimer Erik J
机构信息
Department of Biochemistry, Molecular Biology & Cell Biology, Northwestern University, Evanston, Illinois 60208, USA.
出版信息
Cell. 2005 Nov 18;123(4):543-5. doi: 10.1016/j.cell.2005.11.006.
When an siRNA or miRNA proceeds through the RNA-induced silencing complex assembly pathway, only one of the two approximately 21-nucleotide RNA strands survives in the final, active complex. In this issue of Cell, Matranga et al. (2005) and Rand et al. (2005) reveal the fate of the rejected passenger siRNA strand. Additionally, Gregory et al. (2005) define a heterotrimeric complex from humans that appears to execute dsRNA loading, strand selection, and target mRNA cleavage activities.
当一个小干扰RNA（siRNA）或微小RNA（miRNA）通过RNA诱导沉默复合体组装途径时，在最终的活性复合体中，两条大约21个核苷酸的RNA链中只有一条能够留存。在本期《细胞》杂志中，马特兰加等人（2005年）和兰德等人（2005年）揭示了被舍弃的乘客链小干扰RNA的命运。此外，格雷戈里等人（2005年）确定了一种来自人类的异源三聚体复合体，它似乎执行双链RNA加载、链选择和靶信使核糖核酸切割活性。
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