在无视网膜病变的2型糖尿病患者中用光学相干断层扫描检测早期糖尿病变化。
Detection of early diabetic change with optical coherence tomography in type 2 diabetes mellitus patients without retinopathy.
作者信息
Sugimoto Masahiko, Sasoh Mikio, Ido Masashi, Wakitani Yoshikatsu, Takahashi Chisato, Uji Yukitaka
机构信息
Department of Ophthalmology, Mie University, School of Medicine, Tsu, Japan.
出版信息
Ophthalmologica. 2005 Nov-Dec;219(6):379-85. doi: 10.1159/000088382.
PURPOSE
To detect early diabetic damage in type 2 diabetes mellitus patients with no diabetic retinopathy (NDR) using optical coherence tomography (OCT) and to evaluate OCT as a clinical test.
METHODS
Thirty-two patients with NDR (n = 32) were enrolled. We examined retinal and retinal nerve fiber layer (RNFL) thickness using OCT. Two healthy normal populations were also enrolled for the retinal thickness (n = 48) and RNFL thickness (n = 34). Both OCT measurements were obtained in four areas (temporal, superior, nasal and inferior). The receiver operator characteristic (ROC) curve was generated to evaluate the predictor variables.
RESULTS
Comparing the normal and NDR eyes, retinal thickness significantly increased (p = 0.03) and RNFL thickness significantly decreased (p = 0.02) in the superior areas. The area under the ROC curve was 0.65 for the superior retinal thickness and 0.63 for the superior RNFL thickness.
CONCLUSIONS
Both OCT measurements can detect early retinal damage in NDR patients.
目的
使用光学相干断层扫描（OCT）检测无糖尿病视网膜病变（NDR）的2型糖尿病患者的早期糖尿病损伤，并评估OCT作为一项临床检查的价值。
方法
纳入32例NDR患者（n = 32）。我们使用OCT检查视网膜及视网膜神经纤维层（RNFL）厚度。还纳入了两个健康正常人群用于视网膜厚度（n = 48）及RNFL厚度（n = 34）的研究。两项OCT测量均在四个区域（颞侧、上方、鼻侧和下方）进行。生成受试者操作特征（ROC）曲线以评估预测变量。
结果
比较正常眼和NDR眼，上方区域的视网膜厚度显著增加（p = 0.03），RNFL厚度显著降低（p = 0.02）。上方视网膜厚度的ROC曲线下面积为0.65，上方RNFL厚度的ROC曲线下面积为0.63。
结论
两项OCT测量均能检测出NDR患者的早期视网膜损伤。
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