脱氢氨基酸的去共轭作用：外消旋（E）-乙烯基甘氨酸的立体选择性合成
Deconjugation of dehydroamino acids: stereoselective synthesis of racemic (E)-vinylglycines.
作者信息
Alexander Paul A, Marsden Stephen P, Muñoz Subtil Dulce M, Reader John C
机构信息
School of Chemistry, University of Leeds, Leeds LS2 9JT, United Kingdom.
出版信息
Org Lett. 2005 Nov 24;7(24):5433-6. doi: 10.1021/ol052139q.
PMID:16288524
Abstract
[reaction: see text] A practical and general two-step synthesis of carbamate-protected (E)-vinylglycines from aliphatic aldehydes is reported. The key step involves the kinetic alpha-protonation of dianionic dienolates derived from dehydroamino acids.
摘要
[反应：见正文] 报道了一种从脂肪醛出发实用且通用的两步合成氨基甲酸酯保护的（E）-乙烯基甘氨酸的方法。关键步骤涉及由脱氢氨基酸衍生的双负离子二烯醇盐的动力学α-质子化。
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