Ruiz R Jeanne, Avant Kay C
University of Texas Medical Branch, Galveston, TX, USA.
ANS Adv Nurs Sci. 2005 Oct-Dec;28(4):345-55. doi: 10.1097/00012272-200510000-00006.
There is growing evidence that maternal prenatal stress may be hazardous to infant health. Changes in maternal hormonal and immune function as a result of stress may adversely affect the immune function and neurodevelopment of the fetus. Prenatal stress in the mother may produce lasting effects on the (1) infant's health status, (2) development and function of the infant's immune system, and (3) neurocognitive development of the infant. This article provides a synthesis of current human and animal literature on the effects of maternal prenatal stress on the developing fetus and the infant, with the resulting model evolving out of the framework of psychoneuroimmunology. The intent of the authors is an integrative review. The authors examined the following research question: What effect does maternal prenatal stress have on infants' immune development and neurodevelopment? All relevant studies were reviewed with no exclusion criteria. Major databases (CINAHL, MEDLINE, PsychINFO) were searched using a combination of the following key words: prenatal stress, cytokines, thymus, and infant neurodevelopment.
越来越多的证据表明，母亲产前压力可能对婴儿健康有害。压力导致的母亲激素和免疫功能变化可能会对胎儿的免疫功能和神经发育产生不利影响。母亲的产前压力可能会对（1）婴儿的健康状况、（2）婴儿免疫系统的发育和功能以及（3）婴儿的神经认知发育产生持久影响。本文综合了当前关于母亲产前压力对发育中的胎儿和婴儿影响的人类和动物文献，由此产生的模型是在心理神经免疫学框架的基础上发展而来的。作者的意图是进行一次综合综述。作者研究了以下研究问题：母亲产前压力对婴儿的免疫发育和神经发育有什么影响？对所有相关研究进行了综述，没有排除标准。使用以下关键词组合在主要数据库（CINAHL、MEDLINE、PsychINFO）中进行了搜索：产前压力、细胞因子、胸腺和婴儿神经发育。
