Koyadun Surachart, Bhumiratana Adisak
Office of Disease Prevention and Control 11, Nakhon Si Thammarat, Department of Disease Control, Ministry of Public Health, Nakhon Si Thammarat, Thailand.
Southeast Asian J Trop Med Public Health. 2005 Jul;36(4):822-31.
Myanmar migrants are at increased risk for nocturnally periodic Wuchereria bancrofti causing imported bancroftian filariasis. They have a significant influence on the effectiveness of diethylcarbamazine (DEC) mass treatment at the provincial level in the National Program to Eliminate Lymphatic Filariasis (PELF) during the fiscal years (FY) 2002-2006, in Thailand. Two oral doses of DEC 6 mg/kg are given twice a year to the eligible Myanmar migrants (> or = 2 years old). A 300 mg DEC provocation test is given once a year to all Myanmar migrants with work permits. Effectiveness evaluation parameters, such as cumulative index (CI) and the effectiveness ratio (ER), were obtained after 2 years of the multiple-dose DEC treatment program in Ranong Province, Southern Thailand. By cross-sectional night blood surveys at the end of FY 2003 in two districts of Ranong Province, the microfilarial positive rates (MPR) were 0.8% and 1.2% for Mueang Ranong and Kra Buri, respectively. The MPR in the agricultural (1.5%) and industrial (0.4%) occupations were not significantly different from each other. Our findings suggest that most untreated microfilaremics working in agriculture, with short-term residency in Thailand, may have delayed multiple-dose DEC treatment.
缅甸移民感染夜行性周期出现的班氏吴策线虫从而引发输入性班氏丝虫病的风险增加。在泰国2002 - 2006财政年度全国消除淋巴丝虫病计划(PELF)中,他们对省级乙胺嗪(DEC)群体治疗的效果有重大影响。符合条件的缅甸移民(≥2岁)每年接受两次口服剂量为6毫克/千克的DEC治疗。每年对所有持有工作许可的缅甸移民进行一次300毫克DEC激发试验。在泰国南部拉廊省进行多剂量DEC治疗计划2年后,获得了累积指数(CI)和有效率(ER)等有效性评估参数。在2003财政年度末对拉廊省两个区进行的横断面夜间血液调查中,洛坤和甲米的微丝蚴阳性率(MPR)分别为0.8%和1.2%。农业(1.5%)和工业(0.4%)职业的MPR彼此之间无显著差异。我们的研究结果表明,大多数在农业领域工作、在泰国短期居住的未接受治疗的微丝蚴血症患者可能延迟了多剂量DEC治疗。