Greenfield Susan
University Department of Pharmacology, Mansfield Rd., Oxford OX1 3QT, UK.
Chem Biol Interact. 2005 Dec 15;157-158:211-8. doi: 10.1016/j.cbi.2005.10.032. Epub 2005 Nov 17.
It is now widely accepted that acetylcholinesterase (AChE) also displays non-cholinergic functions, completely independent of cholinergic transmission. Indeed, AChE has been implicated in a variety of trophic and toxic actions in a range of different systems. However, it is still uncertain what part of the AChE molecule may be responsible for these actions, and indeed via what receptor. Recent work has identified a peptide towards the C-terminus of the AChE molecule that appears to have very similar effects to non-cholinergic AChE itself. This action is to enhance calcium entry, in acute and chronic preparations across a trophic-toxic spectrum, depending on concentration applied and/or duration of exposure.
现在人们普遍认为，乙酰胆碱酯酶（AChE）也具有非胆碱能功能，这与胆碱能传递完全无关。事实上，AChE已被证明在一系列不同系统中具有多种营养和毒性作用。然而，仍不确定AChE分子的哪一部分可能负责这些作用，以及实际上是通过何种受体起作用。最近的研究发现，在AChE分子的C末端有一个肽，其作用似乎与非胆碱能AChE本身非常相似。这种作用是增强钙内流，在急性和慢性制剂中，跨越从营养到毒性的范围，这取决于所施加的浓度和/或暴露持续时间。
