前列腺上皮干细胞
Prostate epithelial stem cells.
作者信息
Rizzo S, Attard G, Hudson D L
机构信息
The Bob Champion Prostate Stem Cell Laboratory, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, UK, SM2 5NG.
出版信息
Cell Prolif. 2005 Dec;38(6):363-74. doi: 10.1111/j.1365-2184.2005.00356.x.
Abstract
The prostate gland is the site of the most commonly diagnosed cancer in men in USA and UK, accounting for one in five of new cases of male cancer. Common with many other cancer types, prostate cancer is believed to arise from a stem cell that shares characteristics with the normal stem cell. Normal prostate epithelial stem cells were recently identified and found to have a basal cell phenotype together with expression of CD133. Preliminary data have now emerged for a prostate cancer stem cell that also expresses cell surface CD133 but lacks expression of the androgen receptor. Here we examine the evidence supporting the existence of prostate cancer stem cells and discuss possible mechanisms of stem cell maintenance.
摘要
前列腺是美国和英国男性中最常被诊断出患癌的部位，占男性癌症新发病例的五分之一。与许多其他癌症类型一样，前列腺癌被认为起源于一种与正常干细胞具有共同特征的干细胞。正常前列腺上皮干细胞最近被鉴定出来，发现具有基底细胞表型并表达CD133。现在已经出现了关于前列腺癌干细胞的初步数据，这种干细胞也表达细胞表面CD133，但缺乏雄激素受体的表达。在这里，我们研究支持前列腺癌干细胞存在的证据，并讨论干细胞维持的可能机制。
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