Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands.

作者信息

Sabatucci Joseph P, Ashwell Mark A, Trybulski Eugene, O'Donnell Mary-Margaret, Moore William J, Harnish Douglas C, Chadwick Christopher C

机构信息

Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville PA 19426, USA.

出版信息

Bioorg Med Chem Lett. 2006 Feb 15;16(4):854-8. doi: 10.1016/j.bmcl.2005.11.015. Epub 2005 Nov 21.

DOI:10.1016/j.bmcl.2005.11.015

PMID:16300947

Abstract

The transcription factor nuclear factor-kappaB (NF-kappaB) is a key component in the onset of inflammation. We describe here a series of 4-hydroxyphenyl sulfonamide estrogen receptor (ER) ligands that selectively inhibit NK-kappaB transcriptional activity but are devoid of conventional estrogenic activity.

摘要

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