青少年2型糖尿病：迄今的全貌。

Type 2 diabetes mellitus in youth: the complete picture to date.

作者信息

Gungor Neslihan, Hannon Tamara, Libman Ingrid, Bacha Fida, Arslanian Silva

机构信息

Division of Pediatric Endocrinology, Metabolism, and Diabetes Mellitus, Children's Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA.

出版信息

Pediatr Clin North Am. 2005 Dec;52(6):1579-609. doi: 10.1016/j.pcl.2005.07.009.

DOI:10.1016/j.pcl.2005.07.009

PMID:16301084

Abstract

Type 2 diabetes mellitus is a heterogeneous condition in which the clinical manifestation of hyperglycemia is a reflection of the impaired balance between insulin sensitivity and insulin secretion. Clinical experience and research in youth type 2 diabetes mellitus are in an early stage because of the relative novelty of the condition in pediatrics. This article discusses the amassed information in type 2 diabetes mellitus of youth to date with respect to the epidemiology, pathophysiology, risk factors, clinical presentation, screening, and management strategies.

摘要

2型糖尿病是一种异质性疾病，其中高血糖的临床表现反映了胰岛素敏感性和胰岛素分泌之间平衡受损。由于2型糖尿病在儿科领域相对较新，青少年2型糖尿病的临床经验和研究尚处于早期阶段。本文讨论了迄今为止在青少年2型糖尿病方面积累的有关流行病学、病理生理学、危险因素、临床表现、筛查和管理策略的信息。