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系统性红斑狼疮会是新月体性肾小球肾炎的病因吗?

Can systemic lupus erythematosus be the cause of collapsing glomerulopathy?

作者信息

Marques L P J, Pacheco G G L C, Rioja L S, Nunes S N, Velone S T, Santos O R

机构信息

Gaffrèe and Guinle University Hospital, Department of Medicine, Federal University of State of Rio de Janeiro, Rio de Janeiro, Brazil.

出版信息

Lupus. 2005;14(10):853-5. doi: 10.1191/0961203305lu2162cr.

Abstract

Collapsing glomerulopathy is a severe form of glomerular injury, closely associated with HIV infection, characterized by the collapsing feature of glomerular damage with frequent tubulointerstitial involvement and rapid progression to terminal renal failure. The etiopathogenesis in non-HIV infected patients remains obscure. We reported a patient whose diagnosis of collapsing glomerulopathy (CG) and systemic lupus erythematosus (SLE) was done simultaneously and described the diseases characteristics suggesting that SLE could be an etiologic factor for the induction of this glomerulopathy, clinical evolution and treatment.

摘要

塌陷性肾小球病是一种严重的肾小球损伤形式,与HIV感染密切相关,其特征为肾小球损伤呈塌陷性,常伴有肾小管间质受累,并迅速进展至终末期肾衰竭。非HIV感染患者的发病机制仍不清楚。我们报告了一例同时诊断为塌陷性肾小球病(CG)和系统性红斑狼疮(SLE)的患者,并描述了疾病特征,提示SLE可能是诱发这种肾小球病、临床演变及治疗的一个病因。

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