氨基酸对哺乳动物心脏中胆碱摄取及磷脂酰胆碱生物合成的影响。

The effect of amino acids on choline uptake and phosphatidylcholine biosynthesis in mammalian hearts.

作者信息

Chan M, O K, Man A S, Choy P C

机构信息

Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.

出版信息

Lipids. 1992 Jun;27(6):466-9. doi: 10.1007/BF02536390.

DOI:10.1007/BF02536390

PMID:1630279

Abstract

The uptake of choline in mammalian hearts in the presence of amino acids was examined. Isolated hamster, guinea pig, rat and rabbit hearts were perfused with labeled choline in the presence and absence of amino acids. Neutral amino acids enhanced choline uptake in the hamster heart, but not in the guinea pig, rat and rabbit hearts. Phosphatidylcholine biosynthesis in these hearts was not affected by the presence of amino acids. Choline uptake in the hamster myocytes was also enhanced by neutral amino acid. The enhancement of choline uptake suggests a direct interaction between the amino acid and the transport of choline into the myocardiac cells. The different responses in choline uptake to neutral amino acids indicate that the regulation of choline uptake in the hearts may be different between mammalian species.

摘要

研究了在氨基酸存在的情况下哺乳动物心脏对胆碱的摄取。在有和没有氨基酸的情况下，用标记的胆碱灌注分离的仓鼠、豚鼠、大鼠和兔子的心脏。中性氨基酸增强了仓鼠心脏对胆碱的摄取，但在豚鼠、大鼠和兔子的心脏中没有这种作用。这些心脏中的磷脂酰胆碱生物合成不受氨基酸存在的影响。中性氨基酸也增强了仓鼠心肌细胞对胆碱的摄取。胆碱摄取的增强表明氨基酸与胆碱转运进入心肌细胞之间存在直接相互作用。胆碱摄取对中性氨基酸的不同反应表明，哺乳动物不同物种心脏中胆碱摄取的调节可能不同。