[多巴胺及其衍生物代谢的进展。在严重发育障碍中的应用]

[Development in the metabolism of dopamine and its derivatives. Application to gross development disorders].

作者信息

Martineau J, Garreau B, Barthélémy C, Jouve J, Lelord G

机构信息

INSERM U316, explorations fonctionnelles psychopathologiques, Centre hospitalier régional universitaire, Tours, France.

出版信息

Neurophysiol Clin. 1992 Jun;22(2):179-89. doi: 10.1016/s0987-7053(05)80753-1.

DOI:10.1016/s0987-7053(05)80753-1

PMID:1630417

Abstract

Dopamine (DA) and its metabolites homovanillic acid (HVA) in total, free and conjugated forms, dihydroxyphenylacetic acid (DOPAC) in total, free and conjugated forms, and 3 methoxytyramine (3 MT) levels were determined in the urine of autistic children from 2 years 8 months to 12 years of age and compared to those in normal children of identical age. Very significant group and age effects were found for DA, HVA and 3 MT. In the discussion, results are related to the hypothesis of a disorder in the maturation of the dopaminergic systems in infantile autism.

摘要

测定了年龄在2岁8个月至12岁的自闭症儿童尿液中多巴胺（DA）及其代谢产物总形式、游离形式和结合形式的高香草酸（HVA）、总形式、游离形式和结合形式的二羟基苯乙酸（DOPAC）以及3-甲氧基酪胺（3-MT）的水平，并与同龄正常儿童的水平进行了比较。发现DA、HVA和3-MT存在非常显著的组间和年龄效应。在讨论中，结果与婴儿自闭症中多巴胺能系统成熟障碍的假说相关。