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[优化荷兰的抗生素政策。八、社区获得性肺炎成人抗菌治疗的修订版SWAB指南]

[Optimizing the antibiotics policy in The Netherlands. VIII. Revised SWAB guidelines for antimicrobial therapy in adults with community-acquired pneumonia].

作者信息

Schouten J A, Prins J M, Bonten M, Degener J E, Janknegt R, Hollander J M R, Jonkers R, Wijnands W, Verheij T, Sachs A, Kullberg B J

机构信息

Universitair Medisch Centrum St Radboud, Nijmeegs Universitair Centrum voor Infectieziekten, afd. Algemeen Interne Geneeskunde, Postbus 9101, 6500 HB Nijmegen.

出版信息

Ned Tijdschr Geneeskd. 2005 Nov 5;149(45):2495-500.

PMID:16304886
Abstract

The Dutch Working Party on Antibiotic Policy (SWAB) has revised the 1998 guideline for community-acquired pneumonia (CAP) in light of changing resistance patterns for common pathogens and new developments in epidemiology, diagnostic testing and treatment strategies. The current guideline is applicable to both primary and inpatient care, and has been developed by delegates of all professional organisations involved in the treatment of CAP, following recommendations for evidence-based guideline development. Assessment of a patient's 'severity of illness' at presentation is considered important when choosing an optimal empirical antibiotic regimen for CAP. Severely-ill patients should be treated with antibiotics covering the most important expected pathogens, including Legionella. Assessment of the severity of illness may be facilitated by the use of validated scoring systems like the pneumonia severity index and the 'confusion, urea, respiratory-rate, blood-pressure, 65-years-of-age' (CURB-65) score. Patients can also be stratified based on their location during treatment: in the community, a normal ward or an intensive-care unit. Legionella urine antigen testing is considered an important tool in the process of deciding on an optimal antibiotic regimen for CAP. Empirical therapy should be replaced with pathogen-directed therapy if the causative agent is identified.

摘要

荷兰抗生素政策工作小组(SWAB)根据常见病原体耐药模式的变化以及流行病学、诊断检测和治疗策略的新进展,修订了1998年社区获得性肺炎(CAP)指南。当前指南适用于初级保健和住院治疗,由参与CAP治疗的所有专业组织的代表根据循证指南制定建议共同制定。在为CAP选择最佳经验性抗生素治疗方案时,评估患者就诊时的“疾病严重程度”被认为很重要。重症患者应使用覆盖最重要预期病原体(包括军团菌)的抗生素进行治疗。使用经过验证的评分系统(如肺炎严重程度指数和“意识模糊、尿素、呼吸频率、血压、65岁”(CURB-65)评分)有助于评估疾病严重程度。患者也可根据治疗期间所在位置进行分层:社区、普通病房或重症监护病房。军团菌尿抗原检测被认为是确定CAP最佳抗生素治疗方案过程中的一项重要工具。如果确定了病原体,经验性治疗应改为针对性病原体的治疗。

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