Edgil Dianna, Harris Eva
Division of Infectious Diseases, School of Public Health, University of California, Berkeley, CA 94720-7360, USA.
Virus Res. 2006 Jul;119(1):43-51. doi: 10.1016/j.virusres.2005.10.012. Epub 2005 Nov 22.
A 5'-3' end interaction leading to stimulation of translation has been described for many cellular and viral mRNAs. Enhancement of viral translational efficiency mediated by 5' and 3' untranslated regions (UTRs) has been shown to occur via RNA-RNA interactions or novel RNA-protein interactions. Mammalian RNA viruses make use of end-to-end communication in conjunction with both viral and cellular factors to regulate multiple processes including translation initiation and the switch between translation and RNA synthesis during the viral lifecycle.
许多细胞和病毒mRNA都存在一种导致翻译激活的5'-3'末端相互作用。5'和3'非翻译区(UTR)介导的病毒翻译效率增强已被证明是通过RNA-RNA相互作用或新型RNA-蛋白质相互作用实现的。哺乳动物RNA病毒利用端对端通讯,结合病毒和细胞因子来调节多个过程,包括翻译起始以及病毒生命周期中翻译与RNA合成之间的转换。