急性心肌梗死后支架置入后的QT离散度与左心室功能

QT dispersion and left ventricular function after stent placement in acute myocardial infarction.

作者信息

Ueda Hiroyasu, Hayashi Tomoshige, Tsumura Kei, Yoshimaru Kiyomichi, Nakayama Yasunori, Yoshikawa Junichi

机构信息

Department of Cardiology, Ishikiriseiki Hospital, 18-28, Yayoi, Higashiosaka, Osaka, 579-8026, Japan.

出版信息

Int J Cardiol. 2006 Aug 10;111(2):286-91. doi: 10.1016/j.ijcard.2005.09.022. Epub 2005 Nov 23.

DOI:10.1016/j.ijcard.2005.09.022

PMID:16309762

Abstract

BACKGROUND

QT dispersion is increased in acute myocardial infarction (AMI), but the relation of QT dispersion to left ventricular (LV) function has not yet been fully elucidated. The purpose of this study was to evaluate the relationship between QT dispersion and LV function in patients with successful coronary stenting in AMI.

METHODS

Seventy five patients with AMI who underwent percutaneous transluminal coronary angioplasty (PTCA) were enrolled in this study. Corrected QT dispersion was measured before, immediately after, 24 h after, 48 h after, and 6 months after PTCA. Left ventricular ejection fraction (LVEF) was evaluated by left ventriculography at 6 months after PTCA.

RESULTS

Corrected QT dispersion at 24 h after and 48 h after PTCA were significantly related to LVEF by univariate analysis (r=-0.282, p<0.05 and r=-0.326, p<0.01, respectively). In multiple regression model, corrected QT dispersion at 24 h after and 48 h after PTCA revealed significant associations with LVEF (R(2)=0.441, coefficient=-0.283, p=0.006 and R(2)=0.411, coefficient=-0.225, p=0.039, respectively), but corrected QT dispersion before, immediately after, and 6 months after PTCA were not associated with LVEF.

CONCLUSIONS

Corrected QT dispersion at 24 h after and 48 h after PTCA in AMI correlate with LVEF at 6 months after PTCA.

摘要

背景

急性心肌梗死（AMI）患者的QT离散度增加，但QT离散度与左心室（LV）功能之间的关系尚未完全阐明。本研究的目的是评估AMI患者成功进行冠状动脉支架置入术后QT离散度与LV功能之间的关系。

方法

本研究纳入了75例行经皮腔内冠状动脉成形术（PTCA）的AMI患者。在PTCA术前、术后即刻、术后24小时、术后48小时和术后6个月测量校正QT离散度。在PTCA术后6个月通过左心室造影评估左心室射血分数（LVEF）。

结果

单因素分析显示，PTCA术后24小时和48小时的校正QT离散度与LVEF显著相关（r分别为-0.282，p<0.05和r=-0.326，p<0.01）。在多元回归模型中，PTCA术后24小时和48小时的校正QT离散度与LVEF显著相关（R(2)分别为0.441，系数=-0.283，p=0.006和R(2)=0.411，系数=-0.225，p=0.039），但PTCA术前、术后即刻和术后6个月的校正QT离散度与LVEF无关。