Johnson Cynthia L, Gale Michael
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Trends Immunol. 2006 Jan;27(1):1-4. doi: 10.1016/j.it.2005.11.004. Epub 2005 Nov 23.
A growing family of cellular proteins encoding the caspase activation and recruitment domain (CARD) has a crucial role in immunity by sensing virus infection and signaling antiviral immune defenses. Four independent studies have identified a novel CARD-containing protein, variously called IPS-1, MAVS, VISA and Cardif, which is an essential signaling adaptor of the host defense mediating CARD-CARD interactions with retinoic acid inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDAS), sensors of virus infection. Disruption of this novel signaling pathway by hepatitis C virus (HCV) might provide a foundation for viral persistence.
一个不断增加的编码半胱天冬酶激活和募集结构域（CARD）的细胞蛋白家族，通过感知病毒感染和发出抗病毒免疫防御信号，在免疫中发挥关键作用。四项独立研究鉴定出一种新型含CARD蛋白，分别称为IPS-1、MAVS、VISA和Cardif，它是宿主防御的一种重要信号转导衔接蛋白，介导与视黄酸诱导基因I（RIG-I）和黑色素瘤分化相关基因5（MDA5）（病毒感染传感器）的CARD-CARD相互作用。丙型肝炎病毒（HCV）对这一新型信号通路的破坏可能为病毒持续存在提供基础。
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