（S）-2-乙基苯丙酸衍生物的简洁高效不对称合成：人过氧化物酶体增殖物激活受体α和δ的双重激动剂
Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives: dual agonists for human peroxisome proliferator-activated receptor alpha and delta.
作者信息
Kasuga Jun-ichi, Hashimoto Yuichi, Miyachi Hiroyuki
机构信息
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
出版信息
Bioorg Med Chem Lett. 2006 Feb 15;16(4):771-4. doi: 10.1016/j.bmcl.2005.11.029.
PMID:16321522
Abstract
Optically active (S)-2-ethylphenylpropanoic acid derivatives, dual agonists for human peroxisome proliferator-activated receptor (PPAR) alpha and delta, were efficiently prepared by using Evan's chiral oxazolidinone technique and reductive amide N-alkylation as key steps.
摘要
通过使用埃文斯手性恶唑烷酮技术和还原酰胺N-烷基化作为关键步骤，高效制备了光学活性的(S)-2-乙基苯基丙酸衍生物，该衍生物是人类过氧化物酶体增殖物激活受体(PPAR)α和δ的双重激动剂。
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