[与他莫昔芬使用相关的息肉中发生的子宫内膜癌]

[Endometrial cancers arising in polyps associated with tamoxifen use].

作者信息

Mbatsogo B Anama, Le Bouëdec G, Michy T, Bourdel N, Fouilloux G, Dauplat J

机构信息

Service de chirurgie, centre de lutte contre le cancer (CLCC) Jean-Perrin, Clermont-Ferrand, France.

出版信息

Gynecol Obstet Fertil. 2005 Dec;33(12):975-9. doi: 10.1016/j.gyobfe.2005.10.021.

DOI:10.1016/j.gyobfe.2005.10.021

PMID:16321556

Abstract

OBJECTIVES

To review and describe the anatomoclinical cases of the endometrial cancers arising on polyps during a hormonotherapy by tamoxifen for breast cancer.

PATIENTS AND METHODS

In the surgical inventory 1990-2002 of the benign or malignant uterine lesions investigated by hysteroscopy with dilatation & curettage (D&C) and/or hysterectomy, 108 single or multiple endometrial polyps were encountered and histologically analyzed.

RESULTS

A malignant transformation of polyp was found in 5 instances, meaning a rate of 4.6% i.e. 5/108: 4 cases of adenocarcinoma, 1 case of sarcoma.

DISCUSSION AND CONCLUSION

The existence of endometrial polyps - symptomatic or not - does not seem compatible with the prolonged use of tamoxifen treatment owing the estrogen agonist potential effects of tamoxifen and its well-known hyperplastic and carcinogenic properties for the endometrium. The increased risk of endometrial cancer developing in polyps in this iatrogenic context is estimated between 2.5% and 10% in the literature.

摘要