Kaumann Alberto J, Levy Finn Olav
Department of Physiology, University of Cambridge, CB2 3EG Cambridge, UK.
Br J Pharmacol. 2006 Jan;147(2):128-30. doi: 10.1038/sj.bjp.0706501.
Inotropic responses to 5-hydroxytryptamine (5-HT) in human and porcine atrium can fade, suggesting 5-HT(4) receptor desensitization. De Maeyer et al., however, show in this issue that inhibition of phosphodiesterases with isobutyl-methyl-xanthine prevents fading of 5-HT(4) receptor-mediated responses to 5-HT and the partial agonist prucalopride in porcine atrium.
人类和猪心房对5-羟色胺(5-HT)的变力反应可能会消退,提示5-HT(4)受体脱敏。然而,德迈耶等人在本期杂志中表明,用异丁基甲基黄嘌呤抑制磷酸二酯酶可防止猪心房中5-HT(4)受体介导的对5-HT和部分激动剂普芦卡必利的反应消退。