牛肾上腺髓质22可逆转大鼠的抗伤害性吗啡耐受性。
Bovine adrenal medulla 22 reverses antinociceptive morphine tolerance in the rat.
作者信息
Jiang Jianping, Huang Jian, Hong Yanguo
机构信息
Department of Anatomy and Physiology, Bioengineering School, Fujian Normal University, Fuzhou, Fujian 350000, People's Republic of China.
出版信息
Behav Brain Res. 2006 Mar 15;168(1):167-71. doi: 10.1016/j.bbr.2005.11.002. Epub 2005 Dec 5.
Acute intrathecal (i.t.) bovine adrenal medulla 22 (BAM22, 10 nmol), an endogenous opioid peptide, induced equipotent thermal antinociception in naïve and morphine-tolerant rats while chronic BAM22 resulted in hyperalgesia and decrease in the effectiveness of antinociception. In rats made tolerant to morphine, prior administration of BAM22 (10 nmol, i.t.) significantly resumed antinociceptive response of morphine. The present study demonstrated that BAM22 was able to modulate maintenance of morphine tolerance.
急性鞘内注射（i.t.）内源性阿片肽牛肾上腺髓质22肽（BAM22，10纳摩尔），在未用吗啡和吗啡耐受的大鼠中诱导出等效的热镇痛作用，而慢性给予BAM22则导致痛觉过敏和镇痛效果降低。在对吗啡产生耐受的大鼠中，预先给予BAM22（10纳摩尔，鞘内注射）可显著恢复吗啡的镇痛反应。本研究表明，BAM22能够调节吗啡耐受性的维持。
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