脑膜炎奈瑟菌中“淋球菌遗传岛”的完整形式和变异形式。
Complete and variant forms of the 'gonococcal genetic island' in Neisseria meningitidis.
作者信息
Snyder Lori A S, Jarvis Stephen A, Saunders Nigel J
机构信息
Bacterial Pathogenesis and Functional Genomics Group, Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Department of Computer Science, University of Warwick, Coventry CV4 7AL, UK.
出版信息
Microbiology (Reading). 2005 Dec;151(Pt 12):4005-4013. doi: 10.1099/mic.0.27925-0.
Comparative genome hybridization using the pan-Neisseria microarray identified genes from the gonococcal genetic island (GGI) within Neisseria meningitidis strains of serogroups W-135, H, and Z. While some of these strains contain nearly all of the genes of the GGI, there are differences in the presence of some of these genes between the strains, including between those of the same serogroup. Attempts were then made to determine the location of the GGI in these meningococci. Sequencing of Neisseria gonorrhoeae strain MS11 revealed that the GGI is a conjugative plasmid that can be chromosomally integrated at the dif sites near ung and can also be present in its circularized form. In N. meningitidis, a dif site is present in this location and also serves as the point of chromosomal integration of the GGI in this species.
使用泛奈瑟氏菌微阵列进行的比较基因组杂交鉴定出了血清群W - 135、H和Z的脑膜炎奈瑟氏菌菌株中来自淋球菌遗传岛（GGI）的基因。虽然其中一些菌株几乎包含了GGI的所有基因，但这些菌株之间，包括同一血清群的菌株之间，某些基因的存在情况存在差异。随后尝试确定GGI在这些脑膜炎奈瑟氏菌中的位置。淋病奈瑟氏菌菌株MS11的测序显示，GGI是一种接合质粒，它可以在ung附近的dif位点整合到染色体上，也可以以环状形式存在。在脑膜炎奈瑟氏菌中，该位置存在一个dif位点，它也是GGI在该物种中染色体整合的位点。
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