Jung C S, Schänzer A, Hattingen E, Plate K H, Seifert V
Department of Neurosurgery, Johann-Wolfgang Goethe University Frankfurt, Frankfurt, Germany.
Acta Neurochir (Wien). 2006 Apr;148(4):473-7. doi: 10.1007/s00701-005-0700-6. Epub 2005 Dec 12.
The incidence of diagnosed xanthogranuloma of the sellar region is very low [1, 2, 5, 6]. We report about two cases 1) in a 57-year-old female and 2) in a 5-year-old boy. In both cases radiographic findings revealed an inhomogeneous, contrast enhancing sellar lesion. Histopathology showed the typical features of a xanthogranuloma of the sellar region with cholesterol clefts, lympho-plasmacellular infiltrates, marked hemosiderin deposits, multinucleated foreign body giant cells around cholesterol clefts, accumulation of macrophages and only small epithelial cell clusters [6]. As xanthogranuloma of the sellar region are rarely diagnosed we want to draw attention to this rather unusual diagnosis.
鞍区黄色肉芽肿的诊断发病率非常低[1, 2, 5, 6]。我们报告两例病例,1)一名57岁女性,2)一名5岁男孩。在这两例病例中,影像学检查结果均显示鞍区有不均匀、强化的病变。组织病理学显示鞍区黄色肉芽肿的典型特征,包括胆固醇裂隙、淋巴细胞 - 浆细胞浸润、明显的含铁血黄素沉积、胆固醇裂隙周围的多核异物巨细胞、巨噬细胞聚集以及仅有小上皮细胞簇[6]。由于鞍区黄色肉芽肿很少被诊断出来,我们希望引起大家对这一相当不寻常诊断的关注。