一种新的马来酸依那普利荧光测定法。

A new fluorescent assay for enalapril maleate.

作者信息

de los A Oliva María, Sombra Lorena L, Olsina Roberto A, Masi Adriana N

机构信息

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.

出版信息

J Fluoresc. 2005 Sep;15(5):723-8. doi: 10.1007/s10895-005-2979-3.

DOI:10.1007/s10895-005-2979-3

PMID:16341789

Abstract

A new spectrofluorimetric method for the enalapril maleate monitoring was studied. Enalapril maleate was found to be highly photolabile. This drug was evaluated according to photodegradation assay at pH 2.5 and 6. Enalapril maleate was exposed to UVA-UVB radiations. Under these specific conditions was found as degradation product, the diketopiperazine. The modification of the fluorescent properties of enalapril maleate in solution after exposure UV-radiation and the degradation mechanisms were studied. The photodegradation was followed by the developed spectrofluorimetric assay.

摘要

研究了一种用于监测马来酸依那普利的新荧光分光光度法。发现马来酸依那普利对光高度不稳定。根据在pH 2.5和6条件下的光降解试验对该药物进行评估。马来酸依那普利暴露于UVA - UVB辐射下。在这些特定条件下，发现二酮哌嗪为降解产物。研究了暴露于紫外辐射后溶液中马来酸依那普利荧光性质的变化及其降解机制。通过所建立的荧光分光光度法监测光降解过程。