错配修复缺陷导致的卵巢癌患者的生存情况。
Survival of patients with ovarian cancer due to a mismatch repair defect.
作者信息
Crijnen Th E M, Janssen-Heijnen M L G, Gelderblom H, Morreau J, Nooij M A, Kenter G G, Vasen H F A
机构信息
The Netherlands Foundation for the Detection of Hereditary Tumors, Leiden University Medical Center, Poortgebouw Zuid, 2333 AA, Leiden, The Netherlands.
出版信息
Fam Cancer. 2005;4(4):301-5. doi: 10.1007/s10689-005-6573-2.
PURPOSE
Hereditary non-polyposis colorectal cancer (HNPCC, Lynch syndrome) is characterized by the development of cancer of the colorectum, endometrium and other cancers. Cancer of the ovaries (OC) has frequently been reported in HNPCC. Colorectal cancer associated with HNPCC has a better survival chance compared to sporadic colorectal cancer. It is yet unknown whether patients with OC from HNPCC families (OC-HNPCC) also have a better survival. Therefore, the aim of the study was to compare the survival between patients with OC-HNPCC and a control group.
METHODS
A total of 26 patients with OC were identified from the Dutch HNPCC Registry. A control group (52 cases) matched for age, stage and year of diagnosis was derived from the population-based Eindhoven Cancer Registry. Data on treatment were collected for all patients. Kaplan-Meier analysis was used to calculate the crude survival.
RESULTS
The mean age at diagnosis of OC-HNPCC was significantly lower than the age of sporadic OC (49.5 vs 60.9 years). Compared to sporadic OC, OC-HNPCC was diagnosed at an earlier stage. The survival rate was not significantly different between patients with OC-HNPCC and the controls with sporadic OC. The cumulative 5-year-survival rates were 64.2 and 58.1% respectively.
CONCLUSION
On the basis of our findings, we recommend to treat OC-HNPCC similar to sporadic OC.
目的
遗传性非息肉病性结直肠癌（HNPCC，林奇综合征）的特征是结直肠癌、子宫内膜癌和其他癌症的发生。卵巢癌（OC）在HNPCC中经常被报道。与散发性结直肠癌相比，HNPCC相关的结直肠癌有更好的生存机会。来自HNPCC家族的OC患者（OC-HNPCC）是否也有更好的生存情况尚不清楚。因此，本研究的目的是比较OC-HNPCC患者与对照组之间的生存率。
方法
从荷兰HNPCC登记处共识别出26例OC患者。对照组（52例）根据年龄、分期和诊断年份进行匹配，来自基于人群的埃因霍温癌症登记处。收集了所有患者的治疗数据。采用Kaplan-Meier分析计算粗生存率。
结果
OC-HNPCC诊断时的平均年龄显著低于散发性OC患者（49.5岁对60.9岁）。与散发性OC相比，OC-HNPCC在更早阶段被诊断出来。OC-HNPCC患者与散发性OC对照组之间的生存率没有显著差异。累积5年生存率分别为64.2%和58.1%。
结论
根据我们的研究结果，我们建议对OC-HNPCC的治疗与散发性OC相似。
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