Alexander-Sefre F, Chee N, Spencer C, Menon U, Shepherd J H
Department of Gynaecological Oncology, St. Bartholomew's Hospital, North East London Gynaecological Cancer Centre, London, UK.
Gynecol Oncol. 2006 Jun;101(3):450-4. doi: 10.1016/j.ygyno.2005.11.007. Epub 2005 Dec 15.
To examine intra-operative, short and longer term morbidity associated with Radical Trachelectomy (RT) within our cohort of patients, compared with conventional Radical Hysterectomy (RH).
A retrospective case note review comprising 29 RT and 50 RH patients. Patients who required adjuvant treatment were excluded. Operative data, short-term and long-term complications were recorded. Long-term problems were included only if they had been of persistent nature.
The median age and follow up period for the RH group were 40 years and 60 months and for RT group 30.5 years and 25 months. There were significant differences between RH and RT groups in median operative time (260 versus 187 min), blood loss (1000 versus 400 ml), transfusion requirement (75% versus 12%), analgesic requirement (8 versus 3.5 days) and hospital stay (11 versus 6 days). Bladder hypotonia requiring prolonged catheterisation was more frequent in RH group (P = 0.004). There was no apparent difference in psychosexual problems between the two groups (17 versus 16%). Complications of deep dyspareunia (P = 0.009), excessive vaginal discharge (P = 0.01), and upper thigh parasthesia (P = 0.05) were noted to be significantly higher in the RT group. Specific problems encountered in the RT group included; dysmenorrhea (24%), irregular menstruation (17%), recurrent candidiasis (14%), cervical suture problems (14%), isthmic stenosis (10%) and prolonged amenorrhea (7%).
RT is associated with less operative and short-term morbidity compared with conventional RH. In addition to specific complications associated with RT, in our experience, there are long-term morbidities that are not as commonly observed in RH.
在我们的患者队列中,研究与根治性气管切除术(RT)相关的术中、短期和长期发病率,并与传统根治性子宫切除术(RH)进行比较。
对29例接受RT和50例接受RH的患者进行回顾性病例记录审查。排除需要辅助治疗的患者。记录手术数据、短期和长期并发症。仅纳入持续性的长期问题。
RH组的中位年龄和随访期分别为40岁和60个月,RT组为30.5岁和25个月。RH组和RT组在中位手术时间(260分钟对187分钟)、失血量(1000毫升对400毫升)、输血需求(75%对12%)、镇痛需求(8天对3.5天)和住院时间(11天对6天)方面存在显著差异。RH组中需要长时间导尿的膀胱张力减退更为常见(P = 0.004)。两组之间的性心理问题没有明显差异(17%对16%)。RT组的深部性交困难(P = 0.009)、阴道分泌物过多(P = 0.01)和大腿上部感觉异常(P = 0.05)并发症明显更高。RT组遇到的具体问题包括痛经(24%)、月经不调(17%)、复发性念珠菌病(14%)、宫颈缝合问题(14%)、峡部狭窄(10%)和闭经延长(7%)。
与传统RH相比,RT的手术和短期发病率较低。除了与RT相关的特定并发症外,根据我们的经验,还有一些在RH中不常见的长期发病率。