Rodrigo Tapia J P, García González L A, Alvarez Alvarez I, Cabanillas Farpón R, Suárez Nieto C
Servicio de Otorrinolaringología, Hospital Universitario Central de Asturias, Oviedo, Asturias.
Acta Otorrinolaringol Esp. 2005 Nov;56(9):428-33. doi: 10.1016/s0001-6519(05)78642-8.
infection by oncogenic subtypes of human papillomavirus (HPV) and cyclin D1 gene (CCND1) amplification are frequent events in head and neck squamous cell carcinomas. The objective of this paper is to establish the relationship between the presence of human papillomavirus (HPV) gene sequences and the development of CCND1 gene amplification in these tumours.
59 squamous cell carcinomas of the head and neck were studied for HPV types 6b and 16 and CCND1 gene amplification by polymerase chain reaction.
HPV DNA was detected in 14 tumors (24%). Ten of them were positive for the HPV type 6b and 4 for the HPV type 16. CCND1 gene amplification was found in 15 cases (25%). Although we have found a higher frequency of CCND1 amplification in the HPV-positive cases (36%, versus 22% in the HPV-negative cases), these differences were not statistically significant (P= 0,32).
The presence of HPV gene sequences does not seem to be related to a significative higher incidence of CCND1 gene amplification in the squamous cell carcinomas of the head and neck.
人乳头瘤病毒（HPV）致癌亚型感染和细胞周期蛋白D1基因（CCND1）扩增在头颈部鳞状细胞癌中是常见事件。本文的目的是确定人乳头瘤病毒（HPV）基因序列的存在与这些肿瘤中CCND1基因扩增发生之间的关系。
通过聚合酶链反应研究了59例头颈部鳞状细胞癌中的HPV 6b型和16型以及CCND1基因扩增情况。
在14例肿瘤（24%）中检测到HPV DNA。其中10例HPV 6b型呈阳性，4例HPV 16型呈阳性。15例（25%）发现CCND1基因扩增。尽管我们发现在HPV阳性病例中CCND1扩增频率较高（36%，而HPV阴性病例中为22%），但这些差异无统计学意义（P = 0.32）。
在头颈部鳞状细胞癌中，HPV基因序列的存在似乎与CCND1基因扩增的显著更高发生率无关。
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