高直链玉米淀粉/果胶共混微粒的制备及其特性：技术说明
Preparation and characteristics of high-amylose corn starch/pectin blend microparticles: a technical note.
作者信息
Desai Kashappa Goud H
机构信息
School of Life Sciences and Biotechnology, Korea University, 1, 5-Ka, Anam-Dong, Sungbuk-ku, Seoul-136-701, South Korea.
出版信息
AAPS PharmSciTech. 2005 Sep 30;6(2):E202-8. doi: 10.1208/pt060230.
The HACS/pectin blend microparticles were prepared by spray-drying technique to obtain effective targeted drug release to the colon. The mean particle size of the micro-particles (plain and blend) that were prepared in the present study was between 5.8 and 7.3 μm. The microparticles were positively charged (ζ potential was in the range of 20.3 to 30.8), and the encapsulation efficiency was between 80.1% and 94.7%. The blending of HACS with pectin improved the encapsulation efficiency and decreased the drug dissolution in the gastric condition (pH 1.2) from the pectin-based microparticles. Results of the drug release study indicated that the colonic-controlled drug delivery could be obtained from spray-dried HACS/pectin blend microparticles, and the drug release mechanism was found to be by diffusion or erosion or a combination of both.
通过喷雾干燥技术制备了HACS/果胶共混微粒，以实现药物向结肠的有效靶向释放。本研究制备的微粒（普通微粒和共混微粒）的平均粒径在5.8至7.3μm之间。微粒带正电荷（ζ电位在20.3至30.8范围内），包封率在80.1%至94.7%之间。HACS与果胶的共混提高了包封率，并降低了基于果胶的微粒在胃部环境（pH 1.2）中的药物溶出度。药物释放研究结果表明，喷雾干燥的HACS/果胶共混微粒可实现结肠控释给药，且药物释放机制为扩散或侵蚀或两者结合。
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