Diastereoselective, titanium-mediated cyclization of omega-vinyl tethered imides.
作者信息
Santra Soumava, Masalov Nikolai, Epstein Oleg L, Cha Jin Kun
机构信息
Department of Chemistry, Wayne State University, 5101 Cass Ave, Detroit, Michigan 48202, USA.
出版信息
Org Lett. 2005 Dec 22;7(26):5901-4. doi: 10.1021/ol0525157.
PMID:16354095
Abstract
[reaction: see text] Diastereoselective reductive coupling reactions of omega-vinyl tethered cyclic imides are achieved by a preexisting stereocenter at an allylic position. Particularly noteworthy is the effective use of a 1:2 mixture of Ti(O-i-Pr)4 and n-BuLi to afford the N-acylhemiaminal products in good yields.
摘要
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