Iza-Vallejo B, Mateo-Sierra O, Mosqueira-Centurión B, Ruíz-Juretschke F, Carrillo R
Servicio de Neurocirugía, Hospital General Gregorio Marañón, Madrid, Spain.
Rev Neurol. 2005;41(12):725-32.
Cavernous angiomas are uncommon lesions, with a reported incidence of 0.4 to 0.8%, presenting a controversial management especially regarding their surgical treatment.
To update cavernous angiomas characteristics and management through a deep review of the literature concerning their aetiology, epidemiology, history, signs and symptoms, diagnosis, and surgical and radiosurgical treatment.
Most important advances found in the recent literature include the identification of the genetic basis responsible for the familial form of cavernomatosis (CCM1, CCM2 and CCM3), the identification of the dynamic pattern of these lesions based on their pathology and imaging features, the deeper knowledge on their natural history depending on their supra/infratentorial location, and the main indications for surgical treatment and radiosurgical therapy suggested by the recent series.
海绵状血管瘤是罕见病变，报道的发病率为0.4%至0.8%，其治疗存在争议，尤其是手术治疗方面。
通过对有关海绵状血管瘤的病因、流行病学、病史、体征和症状、诊断以及手术和放射外科治疗的文献进行深入综述，更新海绵状血管瘤的特征和治疗方法。
近期文献中发现的最重要进展包括确定了家族性海绵状血管瘤病（CCM1、CCM2和CCM3）的遗传基础，根据其病理和影像学特征确定了这些病变的动态模式，对其取决于幕上/幕下位置的自然史有了更深入了解，以及近期系列研究提出的手术治疗和放射外科治疗的主要指征。
