使用三维双对比增强T1和T2加权磁共振成像对大鼠心肌活力进行容积评估。
Volumetric assessment of myocardial viability in rats using 3D double contrast enhanced T1 and T2-weighted MRI.
作者信息
Chapon C, Franconi F, Lemaire L, Marescaux L, Legras P, Denizot B, Le Jeune J-J
机构信息
INSERM U 646, Ingénierie de la Vectorisation Particulaire, 10, rue André Boquel, 49100, Angers, France.
出版信息
MAGMA. 2005 Dec;18(6):302-8. doi: 10.1007/s10334-005-0016-9. Epub 2005 Dec 15.
OBJECTIVE
Volumetric evaluation of the myocardial viability post-infarction in rats using 3D in vivo MR imaging at 7 T using injection of an extracellular paramagnetic contrast agent and intravascular superparamagnetic iron oxide nanoparticles in the same imaging session.
MATERIALS AND METHODS
Five hours after induction of permanent myocardial infarction in rats (n=6), 3D in vivo T1- and T2-weighted MR Imaging was performed prior to and after Gd-DOTA injection (0.2 mmol/kg) and prior to and after nanoparticle injection (5 mg Fe/kg) to assess infarct size and myocardial viability.
RESULTS
3D MR Imaging using a successive contrast agent injection showed a difference of infarct size after Gd-DOTA injection on T1-weighted images compared to the one measured on T2-weighted images after Gd-DOTA and nanoparticle injection.
CONCLUSION
The use of 3D T1- and T2-weighted MR Imaging using a double contrast agents protocol made possible the accurate characterization of myocardial infarction volume and allowed the detection of myocardial viability post-infarction in rats.
目的
在7T场强下，通过在同一成像过程中注射细胞外顺磁性造影剂和血管内超顺磁性氧化铁纳米颗粒，利用三维体内磁共振成像对大鼠心肌梗死后的心肌存活情况进行容积评估。
材料与方法
在大鼠（n = 6）永久性心肌梗死诱导5小时后，在注射钆喷酸葡胺（0.2 mmol/kg）前后以及注射纳米颗粒（5 mg Fe/kg）前后进行三维体内T1加权和T2加权磁共振成像，以评估梗死面积和心肌存活情况。
结果
使用连续注射造影剂的三维磁共振成像显示，与钆喷酸葡胺和纳米颗粒注射后在T2加权图像上测量的梗死面积相比，钆喷酸葡胺注射后在T1加权图像上的梗死面积有所不同。
结论
采用双造影剂方案的三维T1加权和T2加权磁共振成像能够准确表征心肌梗死体积，并能检测大鼠心肌梗死后的心肌存活情况。
Zotero 插件