DC-SIGNR基因串联重复多态性与丙型肝炎病毒感染

The tandem-repeat polymorphism of the DC-SIGNR gene in HCV infection.

作者信息

Nattermann J, Ahlenstiel G, Berg T, Feldmann G, Nischalke H D, Müller T, Rockstroh J, Woitas R, Sauerbruch T, Spengler U

机构信息

Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universität Bonn, Bonn, Germany.

出版信息

J Viral Hepat. 2006 Jan;13(1):42-6. doi: 10.1111/j.1365-2893.2005.00652.x.

DOI:10.1111/j.1365-2893.2005.00652.x

PMID:16364081

Abstract

The C-type lectin DC-SIGNR has been shown to bind hepatitis C virus (HCV). Here, we analysed the tandem-repeat polymorphism of the DC-SIGNR gene with respect to intraindividual HCV replication. In a cross-sectional comparison HCV-infected patients (n = 430) and healthy subjects (n = 100) were genotyped for the DC-SIGNR polymorphism using PCR. The distribution of DC-SIGNR alleles did not differ significantly between the two groups. However, HCV-infected patients with 5-, 6-, and 7-repeat alleles had higher HCV-RNA levels when compared with carriers of 4- and 9-repeat alleles (P < 0.05). Thus, the DC-SIGNR polymorphism might affect HCV loads supporting the concept that DC-SIGNR contributes to HCV replication efficacy.

摘要

C型凝集素DC-SIGNR已被证明可结合丙型肝炎病毒（HCV）。在此，我们分析了DC-SIGNR基因的串联重复多态性与个体内HCV复制的关系。在一项横断面比较中，使用聚合酶链反应（PCR）对430例HCV感染患者和100例健康受试者的DC-SIGNR多态性进行基因分型。两组之间DC-SIGNR等位基因的分布没有显著差异。然而，与4重复和9重复等位基因携带者相比，具有5、6和7重复等位基因的HCV感染患者的HCV-RNA水平更高（P < 0.05）。因此，DC-SIGNR多态性可能会影响HCV载量，支持DC-SIGNR有助于HCV复制效率的概念。