Orihashi Masahiro, Shima Yuichiro, Tsuneki Hiroshi, Kimura Ikuko
Department of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan.
Teika Pharmaceutical Company, Toyama, Japan.
Jpn J Ophthalmol. 2005 Nov-Dec;49(6):523-526. doi: 10.1007/s10384-004-0232-2.
To compare the ocular hypotensive effect of nipradilol and timolol in combination with bunazosin in rabbits.
The intraocular pressure (IOP) in normal rabbits was measured using an applanation pneumatonograph. Nipradilol, timolol, and bunazosin were instilled, individually or in combination, into the inferior conjunctival sac.
Nipradilol (0.25%), timolol (0.5%), and bunazosin (0.01%) individually lowered IOP. The IOP-lowering effects of both nipradilol and timolol were significantly enhanced by the combined application of bunazosin (0.01%). In the presence of 5% timolol or 0.1% bunazosin, IOP was further lowered by the addition of nipradilol. The IOP-lowering effect of nipradilol was partly inhibited by pretreatment with c-PTIO (10 mM), a nitric oxide (NO)-trapping agent.
The present study demonstrated that the IOP-lowering effects of nipradilol are due to beta- and alpha1-blocking and NO-donating actions, and bunazosin has an additive effect on the IOP-lowering effect of nipradilol or timolol.
比较尼普地洛和噻吗洛尔联合布那唑嗪对兔眼的降压效果。
使用压平式眼压计测量正常兔的眼压。将尼普地洛、噻吗洛尔和布那唑嗪单独或联合滴入兔眼的下结膜囊。
尼普地洛（0.25%）、噻吗洛尔（0.5%）和布那唑嗪（0.01%）均可单独降低眼压。联合应用布那唑嗪（0.01%）可显著增强尼普地洛和噻吗洛尔的降眼压效果。在存在5%噻吗洛尔或0.1%布那唑嗪的情况下，添加尼普地洛可进一步降低眼压。尼普地洛的降眼压作用部分被一氧化氮（NO）捕获剂c-PTIO（10 mM）预处理所抑制。
本研究表明，尼普地洛的降眼压作用归因于β和α1受体阻断作用以及NO供体作用，布那唑嗪对尼普地洛或噻吗洛尔的降眼压作用具有相加作用。
Zotero 插件