利用近交系小鼠品系鉴定复杂疾病的基因。
Using inbred mouse strains to identify genes for complex diseases.
作者信息
Allayee Hooman, Andalibi Ali, Mehrabian Margarete
机构信息
Department of Preventive Medicine, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-907, USA.
出版信息
Front Biosci. 2006 May 1;11:1216-26. doi: 10.2741/1874.
In recent years, genetic studies in humans have identified a handful of genes that are associated with common disorders, but our understanding of such diseases at the genetic level remains relatively rudimentary. The use of mice to dissect the complex genetic etiology of common disorders offers a viable alternative to human studies since experimental parameters, such as environmental influences, breeding scheme, and detailed phenotyping can be controlled. This review focuses on the utility of mouse genetics for identification of complex disease genes. Atherosclerosis is used as a representative example, followed by an overview for the prospects of successful gene discovery in the future.
近年来，人类遗传学研究已鉴定出一些与常见疾病相关的基因，但我们在基因层面上对这类疾病的了解仍相对初步。利用小鼠来剖析常见疾病复杂的遗传病因，为人类研究提供了一个可行的替代方案，因为诸如环境影响、繁殖方案和详细表型分析等实验参数都可以得到控制。本综述聚焦于小鼠遗传学在鉴定复杂疾病基因方面的效用。以动脉粥样硬化作为一个代表性例子，随后概述未来成功发现基因的前景。
Zotero 插件