年轻人和老年人的固定效应。
Immobilization effects in young and older adults.
作者信息
Urso M L, Clarkson P M, Price T B
机构信息
Department of Exercise Science, University of Massachusetts, 30 Eastman Lane, 110 Totman Building, Amherst, MA, 01003, USA.
出版信息
Eur J Appl Physiol. 2006 Mar;96(5):564-71. doi: 10.1007/s00421-005-0109-1. Epub 2005 Dec 21.
This experiment compared the effects of disuse on the adductor pollicis (AP) muscle in young (YM) and old (OM) men. The AP of the YM and OM was assessed for strength (MVC), compound muscle action potential (CMAP), and volume, and then immobilized for 2 weeks. MVC decreased approximately 22% in the YM, and OM (P<0.001). AP volume was 4.1% (not significant) and 9.5% (P<0.05) less in the YM and OM, respectively. CMAP increased in the OM 0, 24, and 48 h post-immobilization, and did not change in the YM. However, the YM showed a greater decrease in specific force as compared to the OM. YM and OM experienced similar losses in strength, yet muscle volume loss was only significant in OM. Although OM are more susceptible to immediate losses in muscle volume, muscle activation strategies appear to preserve strength during atrophy.
本实验比较了废用对年轻男性（YM）和老年男性（OM）拇收肌（AP）的影响。对YM和OM的AP进行了力量（最大随意收缩，MVC）、复合肌肉动作电位（CMAP）和体积评估，然后固定2周。YM和OM的MVC分别下降了约22%（P<0.001）。YM和OM的AP体积分别减少了4.1%（无显著性差异）和9.5%（P<0.05）。固定后0、24和48小时，OM的CMAP增加，而YM的CMAP没有变化。然而，与OM相比，YM的比肌力下降幅度更大。YM和OM的力量损失相似，但肌肉体积损失仅在OM中显著。虽然OM更容易立即出现肌肉体积损失，但肌肉激活策略似乎在萎缩过程中保持了力量。
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