Arab Sara, Liu Peter P
University of Toronto, Heart & Stroke/Richard Lewar Centre of Excellence, and the Department of Physiology, Toronto General Hospital, Division of Cardiology, Toronto, Canada.
Curr Opin Mol Ther. 2005 Dec;7(6):577-82.
Cardiovascular diseases remain the major cause of mortality and morbidity in the Western world. Heart failure is the most rapidly rising cardiovascular condition and is associated with high mortality. The etiology of heart failure is multiple, ranging from genetic cardiomyopathies to structural modifications to the heart following myocardial infarction or long-standing high blood pressure. Molecular system biology techniques (microarrays and proteomics) in combination with bioinformatics can now provide unique insights into the molecular mechanisms leading to heart failure. Both gene-gene and gene-environment interactions determine the specific phenotype and outcomes in this condition. The identification of these pathways also provides opportunities for the discovery of novel diagnostic and/or prognostic markers, and important therapeutic targets. How recent applications of genomics technologies depict a more complete portrait of molecular events in heart failure is summarized.
心血管疾病仍是西方世界死亡率和发病率的主要原因。心力衰竭是心血管疾病中增长最为迅速的一种，且死亡率很高。心力衰竭的病因多种多样，从遗传性心肌病到心肌梗死后或长期高血压导致的心脏结构改变。分子系统生物学技术（微阵列和蛋白质组学）与生物信息学相结合，现在能够为导致心力衰竭的分子机制提供独特的见解。基因与基因以及基因与环境的相互作用决定了这种疾病的特定表型和结果。这些途径的识别也为发现新的诊断和/或预后标志物以及重要的治疗靶点提供了机会。本文总结了基因组学技术的最新应用如何描绘出心力衰竭中分子事件的更完整图景。
