葡萄糖酸锌的锌药代动力学：与健康男性中氧化锌的比较。

The pharmacokinetics of zinc from zinc gluconate: a comparison with zinc oxide in healthy men.

作者信息

Siepmann M, Spank S, Kluge A, Schappach A, Kirch W

机构信息

Institute of Clinical Pharmacology, Medical Faculty, Technical University, Dresden, Germany.

出版信息

Int J Clin Pharmacol Ther. 2005 Dec;43(12):562-5. doi: 10.5414/cpp43562.

DOI:10.5414/cpp43562

PMID:16372518

Abstract

OBJECTIVE

Zinc supplementation is beneficial in some clinical conditions such as age-related macula degeneration (AMD). It has been suggested that zinc absorption is influenced by the form in which zinc is ingested. Therefore, the pharmacokinetics of zinc gluconate (organic) were compared with those of zinc oxide (inorganic).

METHODS

12 healthy male subjects aged between 21 and 31 years (24 years median) orally received daily doses of 20 mg metal zinc as zinc gluconate and 17.4 mg metal zinc as zinc oxide under randomized crossover conditions for 14 days each with at least 14 days as a washout. Zinc plasma concentrations were measured by means of inductively coupled plasma-atomic emission spectroscopy.

RESULTS

C(max) was found 18.3% (10.3 - 26.3%) higher following multiple-dose administration of zinc gluconate as compared to zinc oxide (mean; 0.95% confidence interval of the relative differences between both treatment conditions; p < 0.05). AUC(0-24h) was noted 8.1% (1.9 - 14.3%) higher after zinc was given as zinc gluconate when compared to zinc oxide (p < 0.05) whereas t(max) did not differ between both treatment conditions.

CONCLUSIONS

Zinc absorption in humans could be improved by zinc complexation with gluconate.

摘要

目的

锌补充剂在某些临床病症中有益，如年龄相关性黄斑变性（AMD）。有人提出锌的吸收受锌摄入形式的影响。因此，比较了葡萄糖酸锌（有机锌）和氧化锌（无机锌）的药代动力学。

方法

12名年龄在21至31岁之间（中位年龄24岁）的健康男性受试者，在随机交叉条件下，每天分别口服20毫克金属锌的葡萄糖酸锌和17.4毫克金属锌的氧化锌，各服用14天，中间至少有14天的洗脱期。通过电感耦合等离子体原子发射光谱法测量血浆锌浓度。

结果

多次服用葡萄糖酸锌后，C(max)比服用氧化锌时高18.3%（10.3 - 26.3%）（平均值；两种治疗条件下相对差异的0.95%置信区间；p < 0.05）。与氧化锌相比，服用葡萄糖酸锌后AUC(0 - 24h)高8.1%（1.9 - 14.3%）（p < 0.05），而两种治疗条件下的t(max)没有差异。