Fujita Masahiro, Ichise Masanori, Zoghbi Sami S, Liow Jeih-San, Ghose Subroto, Vines Douglass C, Sangare Janet, Lu Jian-Qiang, Cropley Vanessa L, Iida Hidehiro, Kim Kyeong Min, Cohen Robert M, Bara-Jimenez William, Ravina Bernard, Innis Robert B
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 1, Room B3-10, I Center Drive, MSC-0135, Bethesda, MD, USA.
Ann Neurol. 2006 Jan;59(1):174-7. doi: 10.1002/ana.20688.
Nicotinic acetylcholine receptors have close interactions with the dopaminergic system and play critical roles in cognitive function. The purpose of this study was to compare these receptors between living PD patients and healthy subjects.
Nicotinic acetylcholine receptors were imaged in 10 nondemented Parkinson's disease patients and 15 age-matched healthy subjects using a single-photon emission computed tomography ligand [(123)I]5-iodo-3-[2(S)-2-azetidinylmethoxy]pyridine. Using an arterial input function, we measured the total distribution volume (V; specific plus nondisplaceable), as well as the delivery (K(1)).
Parkinson's disease showed a widespread significant decrease (approximately 10%) of V in both cortical and subcortical regions without a significant change in K(1).
These results indicate the importance of extending the study to demented patients.
烟碱型乙酰胆碱受体与多巴胺能系统有密切相互作用,在认知功能中起关键作用。本研究的目的是比较帕金森病患者与健康受试者之间的这些受体。
使用单光子发射计算机断层扫描配体[(123)I]5-碘-3-[2(S)-2-氮杂环丁烷基甲氧基]吡啶对10名无痴呆的帕金森病患者和15名年龄匹配的健康受试者的烟碱型乙酰胆碱受体进行成像。使用动脉输入函数,我们测量了总分布容积(V;特异性加非置换性)以及递送率(K(1))。
帕金森病患者的皮质和皮质下区域的V均出现广泛显著降低(约10%),而K(1)无显著变化。
这些结果表明将研究扩展至痴呆患者的重要性。