对一组由单一来源感染的长期存活者中人类免疫缺陷病毒1型nef/长末端重复序列的纵向分析。
Longitudinal analysis of human immunodeficiency virus type 1 nef/long terminal repeat sequences in a cohort of long-term survivors infected from a single source.
作者信息
Churchill Melissa J, Rhodes David I, Learmont Jennifer C, Sullivan John S, Wesselingh Steven L, Cooke Ian R C, Deacon Nicholas J, Gorry Paul R
机构信息
Macfarlane Burnet Institute for Medical Research and Public Health, GPO Box 2284, Melbourne 3001, Victoria, Australia.
出版信息
J Virol. 2006 Jan;80(2):1047-52. doi: 10.1128/JVI.80.2.1047-1052.2006.
Abstract
We studied the evolution of human immunodeficiency virus type 1 (HIV-1) in a cohort of long-term survivors infected with an attenuated strain of HIV-1 acquired from a single source. Although the cohort members experienced differing clinical courses, we demonstrate similar evolution of HIV-1 nef/long-terminal repeat (LTR) sequences, characterized by progressive sequence deletions tending toward a minimal nef/LTR structure that retains only sequence elements required for viral replication. The in vivo pathogenicity of attenuated HIV-1 is therefore dictated by viral and/or host factors other than those that impose a unidirectional selection pressure on the nef/LTR region of the HIV-1 genome.
摘要
我们在一组长期存活者中研究了1型人类免疫缺陷病毒（HIV-1）的进化情况，这些存活者感染了源自单一来源的减毒HIV-1毒株。尽管该队列中的成员经历了不同的临床病程，但我们证明了HIV-1 nef/长末端重复序列（LTR）的相似进化，其特征是序列逐渐缺失，趋向于一种最小化的nef/LTR结构，该结构仅保留病毒复制所需的序列元件。因此，减毒HIV-1的体内致病性是由病毒和/或宿主因素决定的，而不是那些对HIV-1基因组的nef/LTR区域施加单向选择压力的因素。
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