[东北铁线莲皂苷体内抗癌活性的研究]

[Study on the anticancer activities of the Clematis manshrica saponins in vivo].

作者信息

Zhao Ying, Wang Chun-Mei, Wang Bao-Gui, Zhang Chong-Xi

机构信息

College of Chinese Medicinal Material, Jilin Agricultural University, Changchun 130118, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2005 Sep;30(18):1452-3.

PMID:16381470

Abstract

OBJECTIVE

To study the anticancer activity of the Clematis manshrica saponins in vivo.

METHOD

Anticancer activities were tested in mice with experimental tumor (S180, HepA and P388) in vivo.

RESULT

The Clematis manshrica saponins showed a significant anticancer activities on Sarcoma-180, HepA and P388 implanted in mice. In S180 sarcoma, the average tumor inhibition rates were 42.78%, 52.06% and 58.25% (P < 0.05-0.01) respectively; The mean inhibition rates were 37.44%, 52.05% and 59.36% (P < 0.05-0.001) in Hep A tumor separately; while in P388 tumor, the mean inhibition rates were 34.50%, 46.78% and 54.39% (P < 0.05-0.01), respectively.

CONCLUSION

The results indicate that Clematis manshrica has obvious antitumor effects against various transplanted tumor in mice.

摘要

目的

研究东北铁线莲皂苷的体内抗癌活性。

方法

在荷实验性肿瘤（S180、HepA和P388）的小鼠体内测试抗癌活性。

结果

东北铁线莲皂苷对植入小鼠体内的肉瘤-180、HepA和P388显示出显著的抗癌活性。在S180肉瘤中，平均肿瘤抑制率分别为42.78%、52.06%和58.25%（P<0.05-0.01）；在Hep A肿瘤中，平均抑制率分别为37.44%、52.05%和59.36%（P<0.05-0.001）；而在P388肿瘤中，平均抑制率分别为34.50%、46.78%和54.39%（P<0.05-0.01）。