Kumar M D Shaji, Bava K Abdulla, Gromiha M Michael, Prabakaran Ponraj, Kitajima Koji, Uedaira Hatsuho, Sarai Akinori
Department of Bioscience and Bioinformatics, Kyushu Institute of Technology (KIT), 680-4 Kawazu Iizuka, 820-8502 Japan.
Nucleic Acids Res. 2006 Jan 1;34(Database issue):D204-6. doi: 10.1093/nar/gkj103.
ProTherm and ProNIT are two thermodynamic databases that contain experimentally determined thermodynamic parameters of protein stability and protein-nucleic acid interactions, respectively. The current versions of both the databases have considerably increased the total number of entries and enhanced search interface with added new fields, improved search, display and sorting options. As on September 2005, ProTherm release 5.0 contains 17,113 entries from 771 proteins, retrieved from 1497 scientific articles (approximately 20% increase in data from the previous version). ProNIT release 2.0 contains 4900 entries from 273 research articles, representing 158 proteins. Both databases can be queried using WWW interfaces. Both quick search and advanced search are provided on this web page to facilitate easy retrieval and display of the data from these databases. ProTherm is freely available online at http://gibk26.bse.kyutech.ac.jp/jouhou/Protherm/protherm.html and ProNIT at http://gibk26.bse.kyutech.ac.jp/jouhou/pronit/pronit.html.
ProTherm和ProNIT是两个热力学数据库,分别包含通过实验测定的蛋白质稳定性和蛋白质 - 核酸相互作用的热力学参数。这两个数据库的当前版本都大幅增加了条目总数,并通过添加新字段、改进搜索、显示和排序选项来增强了搜索界面。截至2005年9月,ProTherm 5.0版本包含来自771种蛋白质的17,113个条目,这些条目取自1497篇科学文章(数据比上一版本增加了约20%)。ProNIT 2.0版本包含来自273篇研究文章的4900个条目,涉及158种蛋白质。这两个数据库都可以通过万维网界面进行查询。此网页提供了快速搜索和高级搜索功能,以便于从这些数据库中轻松检索和显示数据。ProTherm可在http://gibk26.bse.kyutech.ac.jp/jouhou/Protherm/protherm.html免费在线获取,ProNIT可在http://gibk26.bse.kyutech.ac.jp/jouhou/pronit/pronit.html获取。