Star Kremena V, Song Quingbin, Zhu Andy, Böttinger Erwin P
Albert Einstein College of Medicine, One Gustave L. Levy Place, Box 1243, New York, NY 10029, USA.
Nucleic Acids Res. 2006 Jan 1;34(Database issue):D586-9. doi: 10.1093/nar/gkj027.
Identifying genes that underlie quantitative trait loci (QTL) is a challenging task. Here, we present a new QTL software system, named QTL MatchMaker. The system is designed to integrate and mine QTL information across human, mouse and rat genomes and to annotate functional genomic data. It combines and organizes information from relevant public databases and publications and integrates QTL, physical, genetic and cytogenetic maps across human, mouse and rat. To make this application available to the research community we have developed a website for high-throughput mapping of expressed sequences to QTL and for selection of candidate genes in the physiological genomics context of complex traits. QTL MatchMaker is accessible at http://pmrc.med.mssm.edu:9090/QTL/jsp/qtlhome.jsp.
识别构成数量性状基因座（QTL）的基因是一项具有挑战性的任务。在此，我们展示了一个名为QTL MatchMaker的新的QTL软件系统。该系统旨在整合和挖掘人类、小鼠和大鼠基因组中的QTL信息，并注释功能基因组数据。它结合并整理来自相关公共数据库和出版物的信息，并整合人类、小鼠和大鼠的QTL、物理、遗传和细胞遗传图谱。为了让研究界能够使用此应用程序，我们开发了一个网站，用于将表达序列高通量映射到QTL，并在复杂性状的生理基因组学背景下选择候选基因。可通过http://pmrc.med.mssm.edu:9090/QTL/jsp/qtlhome.jsp访问QTL MatchMaker。
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