阿苯达唑以每日15或30毫克/千克的剂量用于治疗蛛网膜下腔和脑室内囊尾蚴病的试验。
Albendazole trial at 15 or 30 mg/kg/day for subarachnoid and intraventricular cysticercosis.
作者信息
Göngora-Rivera F, Soto-Hernández J L, González Esquivel D, Cook H J, Márquez-Caraveo C, Hernández Dávila R, Santos-Zambrano J
机构信息
Department of Neurology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico.
出版信息
Neurology. 2006 Feb 14;66(3):436-8. doi: 10.1212/01.wnl.0000195887.63124.dc. Epub 2005 Dec 28.
Thirty-six patients with subarachnoid and intraventricular cysticercosis were randomly assigned to receive albendazole at 15 or 30 mg/kg/day plus dexamethasone for 8 days. Results favored a higher dose, with larger cyst reduction on MRI at 90 and 180 days and higher albendazole sulfoxide levels in plasma. An albendazole course at 30 mg/kg/day combined with corticosteroids is safe and more effective than the usual dose. A single treatment was insufficient in intraventricular and giant cysts.
36例患有蛛网膜下腔和脑室内囊尾蚴病的患者被随机分配接受阿苯达唑，剂量为15或30mg/kg/天，加地塞米松，疗程8天。结果显示高剂量组更优，在第90天和180天时MRI上囊肿缩小更明显，且血浆中阿苯达唑亚砜水平更高。阿苯达唑30mg/kg/天的疗程联合皮质类固醇是安全的，且比常规剂量更有效。对于脑室内囊肿和巨大囊肿，单次治疗是不够的。
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