Avian toxicity reference values for perfluorooctane sulfonate.

Toxicity reference values (TRVs) and predicted no effect concentrations (PNECs) were derived for perfluorooctane sulfonate (PFOS) based on the characteristics of a top avian predator. On the basis of the protective assumptions used in this assessment, the benchmarks are protective of avian populations and were based on acute and chronic dietary exposures of northern bobwhite quail and mallard. Toxicological endpoints included mortality, growth, feed consumption, and histopathology. Reproductive endpoints included egg production, fertility, hatchability and survival, and growth of offspring. On the basis of the U. S. Environmental Protection Agency Great Lakes Initiative methodology, and a lowest observable adverse effect concentration (LOAEC) of 10 mg PFOS kg(-1) feed, an uncertainty factor of 36 was derived. The TRV based on PFOS dietary intake was 0.021 mg PFOS kg(-1) body weight day(-1), while for serum, liver, and egg, TRVs were 1.7 microg PFOS mL(-1), 0.6 microg PFOS g(-1) wet weight, and 1.7 microg PFOS mL(-1), respectively. On the basis of the European Commission methodology, a correction factor of 2 (for lowest observed effect level to no observable effect level) and an assessment factor of 30, for a total adjustment of 60, were used to derive PNECs. PNECs based on dietary, mean serum, liver, and egg PFOS concentrations were 0.013 mg PFOS kg(-1) body weight day(-1), 1.0 microg PFOS mL(-1), 0.35 microg PFOS g(-1) wet weight, and 1.0 microg PFOS mL(-1), respectively.