Ewals J A P M
HagaZiekenhuis, locatie Rode Kruis, afd. Reumatologie, Sportlaan 600, 2566 MJ Den Haag.
Ned Tijdschr Geneeskd. 2005 Dec 10;149(50):2810-4.
A 23-year-old man was admitted to hospital with an extremely painful sacroiliitis on the left side. He had been back in The Netherlands for 5 weeks after a one-year stay on a farm in India where he consumed unpasteurised cow's milk almost daily. Three months before admission he had been ill for several weeks with high fever, a painful right hip joint and night sweats. He was diagnosed in India as having coxitis, thought to be due to a Giardia infection. After hospitalisation in The Netherlands, he developed daily high fever with chills and Brucella sacroiliitis was diagnosed via a positive serology, later confirmed by a positive blood culture for Brucella melitensis. The patient was treated with doxycycline and rifampicin but due to persistent fever, gentamicin was later added for 7 days. As a result of nausea related to rifampicin, this was changed to ciprofloxacin. During treatment he also developed a severely painful right coxitis, possibly due to local release of bacterial endotoxins from a previous Brucella infection in India. After three months of antibiotic treatment, he recovered fully. Although brucellosis is a rare imported disease in The Netherlands, the possibility must be kept in mind in cases of arthritis following a stay in the (sub)tropics.
一名23岁男性因左侧骶髂关节炎剧痛入院。他在印度的一个农场待了一年,期间几乎每天都饮用未经巴氏消毒的牛奶,回到荷兰5周后发病。入院前3个月,他持续患病数周,伴有高热、右侧髋关节疼痛和盗汗。在印度,他被诊断为髋关节炎,认为是由贾第虫感染所致。在荷兰住院后,他每天出现高热伴寒战,通过血清学检查呈阳性诊断为布鲁氏菌性骶髂关节炎,后来血培养出羊种布鲁氏菌阳性得以确诊。患者接受了多西环素和利福平治疗,但由于持续发热,后来加用庆大霉素治疗7天。由于利福平引起恶心,遂改用环丙沙星。治疗期间,他还出现了右侧髋关节炎剧痛,可能是由于之前在印度感染布鲁氏菌后细菌内毒素局部释放所致。经过3个月的抗生素治疗,他完全康复。尽管布鲁氏菌病在荷兰是一种罕见的输入性疾病,但对于在(亚)热带地区停留后出现关节炎的病例,必须考虑到这种可能性。