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颌骨骨坏死与双膦酸盐。三例报告。

Osteonecrosis of the jaws and bisphosphonates. Report of three cases.

作者信息

Pastor-Zuazaga Daniel, Garatea-Crelgo Joaquín, Martino-Gorbea Raúl, Etayo-Pérez Amaya, Sebastián-López Cristina

机构信息

Servicio de Cirugía Oral y Maxilofacial, Hospital Virgen del Camino, Pamplona, Navarra.

出版信息

Med Oral Patol Oral Cir Bucal. 2006 Jan 1;11(1):E76-9.

Abstract

Bisphosphonates are recently acquiring increasing relevance in the treatment of several diseases. In line with the increased use of these compounds, cases of mandibular osteonecrosis, and to a lesser extent, maxillary osteonecrosis, are being reported. This necrosis is difficult to treat in patients who usually have a previously limited quality of life. A surgical performance carried out by oral and maxillofacial surgeons, stomatologists and odontologists might lead to bone exposure. A treatment based on conservation and as harmless as possible seems to be the most advisable way of acting with these patients in order to minimize the incidence and treat the complications, once the lesions have been ascertained. We report three cases treated in our service of osteonecrosis of the jaws after exodontics. This side effect should be remembered before starting any surgical treatment in these patients.

摘要

双膦酸盐类药物在多种疾病的治疗中日益受到关注。随着这些化合物使用的增加,下颌骨坏死病例以及程度较轻的上颌骨坏死病例不断被报道。这种坏死在生活质量通常本就有限的患者中难以治疗。口腔颌面外科医生、口腔医师和牙医师进行的外科手术可能导致骨暴露。一旦确定病变,基于保守且尽可能无害的治疗似乎是针对这些患者采取行动的最明智方式,以尽量减少发病率并治疗并发症。我们报告了在我们科室治疗的3例拔牙后颌骨坏死病例。在对这些患者开始任何外科治疗之前,都应牢记这种副作用。

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