针对自身免疫性疾病的T细胞靶向免疫疗法。

T cell targeted immunotherapy for autoimmune disease.

作者信息

Lee Erica, Sinha Animesh A

机构信息

Department of Dermatology, Weill Medical College of Cornell University, New York, NY, USA.

出版信息

Autoimmunity. 2005 Dec;38(8):577-96. doi: 10.1080/08916930500418136.

DOI:10.1080/08916930500418136

PMID:16390811

Abstract

Much emphasis has been placed on the so-called "biologics" in the treatment of immune disorders within the last few years. Here we discuss the expanding horizon of potential strategies for immunotherapies targeting T lymphocytes as key effectors and regulators of autoimmunity. We review emerging reagents in a variety of animal models and human disorders that may offer new therapeutic options in current or modified iterations.

摘要

在过去几年里，所谓的“生物制剂”在免疫疾病治疗中受到了广泛关注。在此，我们将探讨针对作为自身免疫关键效应器和调节因子的T淋巴细胞的免疫治疗潜在策略的广阔前景。我们回顾了各种动物模型和人类疾病中出现的试剂，这些试剂可能在当前或经过改进的迭代中提供新的治疗选择。