Wong K K, Potts J E, Etheridge S P, Sanatani S
Division of Pediatric Cardiology, British Columbia Children's Hospital, Vancouver, British Columbia, V6H 3V4, Canada.
Pediatr Cardiol. 2006 Mar-Apr;27(2):199-203. doi: 10.1007/s00246-005-1126-x.
Supraventricular tachycardia is the most common pediatric arrhythmia, but there is no consensus and little evidence to guide its treatment. We sent a questionnaire to pediatric cardiologists in North America to assess the current practice pattern. Of 1534 surveys mailed, 352 (23%) were returned and 295 (19%) had complete data for analysis. In the acute setting, 11 different medications were chosen. The most commonly used in the infant without preexcitation were digoxin (42%), procainamide (21%), esmolol (13%), propranolol (10%), and amiodarone (8%). In the infant with preexcitation, propranolol (34%), procainamide (23%), esmolol (17%), amiodarone (11%), and digoxin (6%) were used. In the chronic setting, 8 different medications were chosen. The most commonly used in this scenario were digoxin (52%), propranolol (33%), amiodarone (4%), and sotalol (3%). In the infant with preexcitation, propranolol (70%), amiodarone (6%), digoxin (6%), atenolol (6%), and flecainide (5%) were used. Medication choices were influenced by additional electrophysiology training and preexcitation. Digoxin was used less in the setting of preexcitation. There are no comparative trials to explain the different medication choices. Although a number of medications may be efficacious, a randomized clinical trial is needed to offer further guidance.
室上性心动过速是最常见的小儿心律失常,但在其治疗方面尚无共识且几乎没有证据可循。我们向北美儿科心脏病专家发送了一份调查问卷,以评估当前的治疗模式。在邮寄的1534份调查问卷中,有352份(23%)被退回,295份(19%)有完整数据可供分析。在急性情况下,选择了11种不同药物。在无预激的婴儿中,最常用的是地高辛(42%)、普鲁卡因胺(21%)、艾司洛尔(13%)、普萘洛尔(10%)和胺碘酮(8%)。在有预激的婴儿中,使用了普萘洛尔(34%)、普鲁卡因胺(23%)、艾司洛尔(17%)、胺碘酮(11%)和地高辛(6%)。在慢性情况下,选择了8种不同药物。在这种情况下最常用的是地高辛(52%)、普萘洛尔(33%)、胺碘酮(4%)和索他洛尔(3%)。在有预激的婴儿中,使用了普萘洛尔(7%)、胺碘酮(6%)、地高辛(6%)、阿替洛尔(6%)和氟卡尼(5%)。药物选择受额外的电生理培训和预激的影响。在有预激的情况下,地高辛的使用较少。尚无比较试验来解释不同的药物选择。尽管许多药物可能有效,但仍需要进行随机临床试验以提供进一步指导。