Somu Ravindranadh V, Boshoff Helena, Qiao Chunhua, Bennett Eric M, Barry Clifton E, Aldrich Courtney C
Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, Minnesota 55455, USA.
J Med Chem. 2006 Jan 12;49(1):31-4. doi: 10.1021/jm051060o.
A rationally designed nucleoside inhibitor of Mycobacterium tuberculosis growth (MIC(99) = 0.19 microM) that disrupts siderophore biosynthesis was identified. The activity is due to inhibition of the adenylate-forming enzyme MbtA which is involved in biosynthesis of the mycobactins.
一种经合理设计的结核分枝杆菌生长核苷抑制剂（MIC(99)=0.19微摩尔）被鉴定出来，它能破坏铁载体生物合成。该活性归因于对参与分枝菌素生物合成的腺苷酸形成酶MbtA的抑制作用。
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