Durdux Catherine
Onco-radiothérapie, Hôpital européen Georges Pompidou, 20, rue Leblanc, 75015 Paris.
Bull Cancer. 2005 Dec;92(12):1073-7.
Bladder cancer is an urologic common tumor after prostate carcinoma. Radical treatment of localized invasive tumor is based on cystectomy. Surgical mutilation could be important when Bricker's urinary derivation is performed. Moreover, delated metastasis appeared frequently in spite of radical surgery. So, for selected patients, chemoradiotherapy is a valid alternative treatment to cystectomy. Cisplatin or derivatives were administered concurrently to radiation therapy up to 60-65 Gy. Patients underwent control cystoscopy at midtime of treatment in order to select responders from non responders. This review summarizes the main published series of radiochemotherapy in invasive bladder cancer. Results for local control, survivals, bladder preservation rates and toxicity are presented.
膀胱癌是继前列腺癌之后泌尿外科常见的肿瘤。局限性浸润性肿瘤的根治性治疗以膀胱切除术为基础。当采用Bricker尿流改道术时,手术致残可能很严重。此外,尽管进行了根治性手术,但延迟转移仍经常出现。因此,对于选定的患者,放化疗是膀胱切除术的一种有效的替代治疗方法。顺铂或其衍生物与高达60 - 65 Gy的放射治疗同时进行。患者在治疗中期接受对照膀胱镜检查,以便从无反应者中选择有反应者。本综述总结了已发表的关于浸润性膀胱癌放化疗的主要系列研究。给出了局部控制、生存率、膀胱保留率和毒性的结果。